Crinetics is seeking a highly motivated and collaborative scientist with experience in GPCR mechanistic pharmacology to join our growing and dynamic Biology team. The successful candidate will be an integral member of multidisciplinary teams working on unmet needs in endocrine related diseases and striving to make a real difference in the lives of patients. Their primary role will be lab based, providing in vitro pharmacology data that supports lead optimization campaigns, mechanism of action studies, and new target efforts in an environment that values scientific integrity and quality, and fosters learning, open communication, collaboration, and teamwork.
ESSENTIAL FUNCTIONS AND RESPONSIBILITIES:
These may include but are not limited to:
Conceive, develop, and execute methods exploring GPCR pharmacology, mechanism, and signaling
Critically analyze and interpret data into meaningful understanding of small molecule SAR and compound selection
Translate and effectively communicate results to multidisciplinary colleagues and contribute to team discussions
Maintain familiarity with current scientific literature and pertinent new technologies and adapt concepts from the literature to bench research
ADDITIONAL FUNCTIONS AND RESPONSIBILITIES:
Other duties as assigned
EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES:
PhD in Biology, Biochemistry, Pharmacology or related discipline and a minimum of 12 years of experience or equivalent in laboratory experience
Experience in drug discovery and small molecule GPCR pharmacology is preferred
Extensive and in-depth technical proficiency in biochemical, cell-based functional, and radioligand binding assay systems and demonstrated ability to ensure high quality data
Outstanding experimental design, problem-solving, and data analysis skills and the ability to independently establish in vitro pharmacologic approaches to achieve program goals
Familiarity with current scientific literature and pertinent new technologies and the ability to adapt concepts from literature to bench research to support ongoing studies.
Ability to effectively multitask and advance various projects simultaneously without compromising data quality or reproducibility
Ability to work independently as well as in a cross functional team and matrix environment
Management experience preferred but not required
Excellent communication (written and verbal), time management, organizational and interpersonal skills to ensure operational excellence of daily laboratory needs and timely execution of shared team deliverables
TECHNICAL KNOWLEDGE REQUIRED:
Equipment: PC, scanners, voice mail and e-mail systems, and common office machines, or ability to be trained. Knowledge of other equipment required: standard biology lab equipment (microplate readers, laboratory automation, etc.)
Software Knowledge: Windows, MS Office (Outlook, Word, Excel, PowerPoint), GraphPad Prism or equivalent statistical and graphing software.
EFFORT REQUIRED/ENVIRONMENTAL CONDITIONS:
Physical Activities: On a continuous basis, sit at desk for a long period of time; intermittently answer telephone and write or use a keyboard to communicate through written means. Some walking and lifting up to 20 lbs. may be required. The noise level in the work environment is usually low to moderate. The physical demands described above are representative of those that must be met by an employee to successfully perform the essential functions and responsibilities of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions and responsibilities.
Laboratory Activities, if applicable: Biology, chemical laboratory and tissue culture environments experience needed. Environmental health and safety requirements also apply.
Travel may be required up to 10% of your time
Crinetics Pharmaceuticals Inc. is a rare endocrine and endocrine-related cancer therapeutics company. Crinetics’ benefit package includes health insurance, stock options, a 401k, paid time off, and the company provides a dog-friendly work environment.