Sorrento Therapeutics, Inc. is a clinical stage and commercial biopharmaceutical company focused on delivering innovative and clinically meaningful therapies to address unmet medical needs. Our vision is to leverage our proprietary G-MAB™ library in conjunction with proprietary targeted delivery modalities to generate the next generation of therapeutics for treating cancer, autoimmune, inflammatory, viral and neurodegenerative diseases. These modalities include proprietary chimeric antigen receptor T-cell therapy (CAR-T), dimeric antigen receptor T-cell therapy (DAR-T™), antibody drug conjugates (ADCs), oncolytic virus (Seprehvec™), lymphatic drug targeting (SOFUSA®), as well as bispecific antibody approaches. We are additionally developing pain management solutions, including our clinical candidates resiniferatoxin (RTX) and SEMDEXA™. In response to the global SARS-CoV-2 (“COVID-19”) pandemic, we are also developing and conducting clinical studies for potential coronavirus antiviral therapies and vaccines, including Abivertinib, COVI-MSC™, COVI-AMG™, COVIDROPS™, and COVI SHIELD™, and diagnostic test solutions, such as COVISTIX™ and COVITRACK™.
We attract smart people who play well with others. We’re small enough for your ideas to make a big impact, and large enough to offer you opportunities to grow professionally at any stage of your career.
If you’re a quick learner, enjoy working in the biotech industry, and share our mission of providing ground-breaking impact to medicine, each other, and our patients, Sorrento Therapeutics is the place for you!
Sorrento Therapeutics, Inc. is a federal government contractor and, in compliance with its obligations under current federal regulations and guidance from the Safer Federal Workforce Task Force, Sorrento requires all employees, including newly hired employees, to present proof of vaccination against COVID-19, unless the employee is legally entitled to an accommodation. For further information, please refer to the Safer Federal Workforce Task Force’s 2021 Guidance for Federal Contractors and Subcontractors (Updated November 10, 2021), available at: https://www.saferfederalworkforce.gov/contractors/.
WHAT WE ARE LOOKING FOR:
Cytimm Therapeutics, a subsidiary of Sorrento Therapeutics, is developing a pipeline of preclinical programs including engineered cytokines and monoclonal antibodies, with novel pharmacological properties and proven developmental path forward.
We are seeking highly skilled and motivated employees who are looking for growth opportunities in a fast paced, startup-like environment. The main purpose of the job is to support pre-IND research and development of Cytimm’s pipeline programs in the field of ImmunoOncology and autoimmune diseases.
WHAT YOU’LL DO:
Executing various protein engineering, production and characterization assays to advance innovative biotherapeutic products through discovery and pre-clinical development stages.
Design, express, purification and analysis of biotherapeutics (including monoclonal antibodies, fusion proteins, and protein conjugates) by common methods at lab scale.
Lead the process devleopment for industrial manufacturing in collaboration with our internal CMC teams, as part of pre-IND activities for the leading immunotherapy programs.
Manages scientific projects by interfaces with cross-functional groups, come-up with the project timeine, identify any issues and solve the trouble on the way forward.
Promotes and leads efforts in publishing manuscripts in peer reviewed journals and/or oral presentations at scientific meetings, national, or international meetings.
Establishes goals for personnel and other resources. Provides intellectual insight into scientific data and results.
Mentors and motivates subordinates to achieve organizational goals.
Determines the relevance and value of external knowledge and makes recommendations.
Other duties as assigned
EDUCATION AND QUALIFICATIONS:
Ph.D. with relevant academia or industry experience.
Strong background in Protein Chemistry and Biochemistry
Knowledgable in design and engineering of constructs for fusion proteins, antibodies and protein bioconjugations.
Experience in purification of recombinant proteins and monoclonal antibodies (AKTA system, IEX, SEC, HIC, HPLC).
Knowledge in analytical characterization and QC of biologics therapeutic product CMC development.
Maintain and monitor laboratory equipment
Present and prepare experimental results by following Good Document Practices.
Excellent communication and documentation skills required.
Excellent attention to detail and problem solving skills.
The ability to work in a team-oriented environment focused on project deliverables is critical.
Flexibility and ability to respond to changing priorities and project directions.
Apply information obtained from internal and published sources to develop hypotheses as well as design and execute experiments for clinical-enabling and other critical go/no-go program decisions.
Work collaboratively to obtain protocols, tools and reagents needed to execute experiments.
Contribute to the preparation of technical documents, project report summaries, laboratory protocols, patents, and other regulatory documents.
Maintain good communication and collaborate with internal team and CROs.
Support scientists who are on the leading edge of immunotherapies for the treatment of cancer.
Earn a competitive salary that allows you to focus your attention on your passion.
A comprehensive benefits package including: medical, dental, vision, life and disability insurance, matching 401k, company paid holidays, and Flexible PTO, plus equity-based compensation.
If this sounds like the right career to fit your personality and interests, please apply, we’re looking forward to meeting you!
Principals only. Recruiters, please do not contact this job poster.
Sorrento Therapeutics, Inc. is an Equal Opportunity Employer.
Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities
The contractor will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information. 41 CFR 60-1.35(c)